Super-Resolution Microscopy Systems for Beyond-Diffraction Cellular Imaging
Break the optical resolution barrier to reveal unseen molecular details within cells.
Super-Resolution Microscopes: Bridging the Gap Between Light and Electron Microscopy
Super-resolution microscopes revolutionize the visualization of biological structures previously obscured by the diffraction limit of conventional light microscopy. Utilizing techniques like STED (Stimulated Emission Depletion), SIM (Structured Illumination Microscopy), and PALM/STORM (Photoactivated Localization Microscopy/Stochastic Optical Reconstruction Microscopy), these instruments achieve resolution down to 20–50 nanometers.
At Cellular Tissue Analysis, based in Indianapolis, IN, we provide cutting-edge super-resolution platforms tailored to life sciences, nanomedicine, and molecular diagnostics. Our systems combine high-end optics, advanced image reconstruction software, and robust automation to empower North American laboratories in revealing the invisible.
System Architecture: Advanced Optics, Software, and Cloud Integration
In addition to our proprietary systems, we support live-cell platforms from global leaders like GAO Tek Inc. and GAO RFID Inc.—combining precision optics with automation-ready configurations.
Hardware Components
- Precision STED lasers and TIRF illumination sources:
Optical & Imaging Sensors – enable super-resolution and surface-selective imaging with tightly focused laser excitation for nanoscale structural studies. - Piezo-driven XYZ scanning stages:
Motion & Position Sensors – offer nanometer-level accuracy for rapid and repeatable sample navigation in high-speed, 3D imaging applications. - Environmental control chambers for live-cell imaging:
Environmental & Agriculture Sensors – maintain tightly regulated temperature, humidity, and gas conditions to preserve cell viability and physiological relevance during long-term imaging.
Software Suite
- Image deconvolution and reconstruction algorithms
- Real-time control of illumination patterns and scanning trajectories
- Drift correction and z-stack processing
- Super-resolution rendering and artifact suppression
Cloud & Remote Tools
- Secure backup of large datasets
- Cloud-based stitching and visualization
- Remote access for collaboration and secondary analysis
- LIMS and ELN compatibility for seamless documentation
Key Features & Functionalities
Resolution down to 20
nm in x-y and 50
nm in z-axis
Multiple super-resolution modes (STED, SIM, PALM/STORM) in one platform
Live-cell imaging compatible with low phototoxicity
Fast acquisition for dynamic cellular processes
Multicolor imaging and spectral unmixing
Application Areas
- Synaptic vesicle tracking in neurons
- Mitochondrial dynamics and protein complex organization
- Virus-host interaction studies
- Cancer biomarker co-localization
- Stem cell fate and differentiation pathway mapping
Key Advantages
- Visualize intracellular nanostructures like cytoskeletons, organelle boundaries, and protein clusters
- Non-invasive imaging of live cells with sub-diffraction precision
- Accelerate discoveries in neurobiology, virology, and oncology
- Extensive technical support, installation, and user training across North America
- Flexible configuration for fixed-tissue, in vitro, and in vivo models
Integration & Workflow Automation
- Interfaces with AI-based image analysis platforms
- Compatible with sample preparation robotics and hybrid microscopy suites
- Modular add-ons for adaptive optics, photomanipulation, and correlative EM
- SDK and API access for custom lab integration
Certifications & Compliance
- ISO 13485 and ISO 9001 certified manufacturing partners
- CE-marked for research and clinical applications
- FDA CFR 21 Part 11 compliant image logging systems
- Canadian and U.S. electrical and radiation safety standards
Industries We Serve
Neurobiology and Brain Research Centers
Cancer Research Institutes
Pharmaceutical and Biotech R&D
Academic and Core Imaging Facilities
Infectious Disease and Immunology Labs
Case Studies
Want to achieve nanometer precision in your imaging pipeline?
Get in touch with Cellular Tissue Analysis for personalized solutions and demos.