Super-Resolution Microscopy Systems for Beyond-Diffraction Cellular Imaging
Break the optical resolution barrier to reveal unseen molecular details within cells.
Bridging the Gap Between Light and Electron Microscopy
Super-resolution microscopes revolutionize the visualization of biological structures previously obscured by the diffraction limit of conventional light microscopy. Utilizing techniques like STED (Stimulated Emission Depletion), SIM (Structured Illumination Microscopy), and PALM/STORM (Photoactivated Localization Microscopy/Stochastic Optical Reconstruction Microscopy), these instruments achieve resolution down to 20–50 nanometers.
At Cellular Tissue Analysis, based in Indianapolis, IN, we provide cutting-edge super-resolution platforms tailored to life sciences, nanomedicine, and molecular diagnostics. Our systems combine high-end optics, advanced image reconstruction software, and robust automation to empower North American laboratories in revealing the invisible.
System Architecture: Advanced Optics, Software, and Cloud Integration
In addition to our proprietary systems, we support live-cell platforms from global leaders like GAO Tek Inc. and GAO RFID Inc.—combining precision optics with automation-ready configurations.
Hardware Components
a. Precision STED lasers and TIRF:
Optical & Imaging Sensors
Enable super-resolution and surface-selective imaging with tightly focused laser excitation for nanoscale structural studies.
b. Piezo-driven XYZ scanning stages:
Motion & Position Sensors
Offer nanometer-level accuracy for rapid and repeatable sample navigation in high-speed, 3D imaging applications.
c. Environmental control chambers for live-cell imaging:
Environmental & Agriculture Sensors
Maintain tightly regulated temperature, humidity, and gas conditions to preserve cell viability and physiological relevance during long-term imaging.
Software Suite
- Image deconvolution and reconstruction algorithms
- Real-time control of illumination patterns and scanning trajectories
- Drift correction and z-stack processing
- Super-resolution rendering and artifact suppression
Cloud & Remote Tools
- Secure backup of large datasets
- Cloud-based stitching and visualization
- Remote access for collaboration and secondary analysis
- LIMS and ELN compatibility for seamless documentation
Key Features and Functionalities
Resolution down to 20 nm in x-y and 50 nm in z-axis
Multiple super-resolution modes (STED, SIM, PALM/STORM) in one platform
Live-cell imaging compatible with low phototoxicity
Fast acquisition for dynamic cellular processes
Multicolor imaging and spectral unmixing
Integration & Workflow Automation
Interfaces with AI-based image analysis platforms
Compatible with sample preparation robotics and hybrid microscopy suites
Modular add-ons for adaptive optics, photomanipulation, and correlative EM
SDK and API access for custom lab integration
Key Advantages
- Visualize intracellular nanostructures like cytoskeletons, organelle boundaries, and protein clusters
- Non-invasive imaging of live cells with sub-diffraction precision
- Accelerate discoveries in neurobiology, virology, and oncology
- Extensive technical support, installation, and user training across North America
- Flexible configuration for fixed-tissue, in vitro, and in vivo models
Application Areas
- Synaptic vesicle tracking in neurons
- Mitochondrial dynamics and protein complex organization
- Virus-host interaction studies
- Cancer biomarker co-localization
- Stem cell fate and differentiation pathway mapping
Industries We Serve
- Neurobiology and Brain Research Centers
- Cancer Research Institutes
- Pharmaceutical and Biotech R&D
- Academic and Core Imaging Facilities
- Infectious Disease and Immunology Labs
Certifications & Compliance
- ISO 13485 and ISO 9001 certified manufacturing partners
- CE-marked for research and clinical applications
- FDA CFR 21 Part 11 compliant image logging systems
- Canadian and U.S. electrical and radiation safety standards
Case Studies
U.S – Neuroscience Research Institute, San Diego, CA
Installed a dual-mode STED/SIM system to study dendritic spine plasticity. Enabled nanometer-resolution tracking of actin remodeling during memory encoding.
Canadian – Immunopathology Center, Montreal, QC
Utilized PALM/STORM platforms for precise localization of immune checkpoint proteins in cancer biopsies. Improved biomarker validation and spatial analysis.
U.S – Advanced Virology Lab, Boston, MA
Deployed live-cell SIM for visualizing viral entry and trafficking in epithelial cells. Enabled real-time observations of membrane fusion events at nanoscale resolution.
Want to achieve nanometer precision in your imaging pipeline?
Get in touch with Cellular Tissue Analysis for personalized solutions and demos.